assay
>99% (TLC)
form
chloroform solution
packaging
pkg of 1 × 4 mL (141101C-100mg), pkg of 5 × 4 mL (141101C-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
25 mg/mL (141101C-100mg), 25 mg/mL (141101C-500mg)
lipid type
lipid extracts
shipped in
dry ice
storage temp.
−20°C
General description
Brain Extract Polar comprises phosphatidylethanolamine as major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.
Application
Brain Extract Polar has been used as an artificial membrane solution component for permeability studies. It may be used for coating donor plate during parallel artificial membrane permeability assay (PAMPA) to study blood-brain barrier penetration. It may be used in liposome preparation for dynamin self-assembly assay.
Biochem/physiol Actions
Brain lipid, especially the polar fraction plays a key role in the inhibition of prion seeded amyloid formation. Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.
Packaging
5 mL Clear Glass Sealed Ampule (141101C-100mg)
5 mL Clear Glass Sealed Ampule (141101C-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito TPC, et al.
European Journal of Medicinal Chemistry, 145(10), 431-444 (2018)
Kalirin12 interacts with dynamin
Xin X, et al.
BMC Neuroscience, 10(1), 61-61 (2009)
Estefanía de Munck et al.
PloS one, 11(9), e0162723-e0162723 (2016-09-16)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 141101C-100MG | 04061838169037 |
| 141101C-500MG | 04061838169044 |