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关于此项目
经验公式（希尔记法）:
C31H54N5O11P
化学文摘社编号:
分子量:
703.76
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
16:0-06:0 NBD PA, Avanti Research™ - A Croda Brand 810173P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810173P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810173P
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The phospholipid contains phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) PA is a fluorescent analog with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to the sn-2 fatty acid of PA.
Application
16:0-06:0 NBD PA 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate is suitable to measure the substrate transport by an increase in cellular fluorescence to determine type 4 P-type ATPases (P4-ATPase) discrimination and its glycerophospholipid (GPL) substrate selection through the directed evolution of a sphingomyelin (SM) flippase.
Biochem/physiol Actions
Phosphatidic acid (PA) is crucial for intracellular signaling involved various cellular processes including membrane trafficking and sperm hyper-activation. It plays a vital role in lipid synthesis.
Packaging
5 mL Amber Glass Screw Cap Vial (810173P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 810173P-1MG | 04061835190041 |