产品名称
06:0 PI(3,4,5)P3, 1,2-dihexanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850176P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850176P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850176P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]
InChI key
YTZPLJSHLDNARZ-KPKFNREXSA-N
General description
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Biochem/physiol Actions
Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) acts as a lipid second messenger. It is capable of triggering protein kinase B (PKB) phosphorylation. PI(3,4,5) may play a role in the modulation of synaptic activity.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (850176P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850176P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Thang Manh Khuong et al.
Neuron, 77(6), 1097-1108 (2013-03-26)
PI(3,4,5)P3 is a low-abundance lipid thought to play a role in the regulation of synaptic activity; however, the mechanism remains obscure. We have constructed novel split Venus-based probes and used superresolution imaging to localize PI(3,4,5)P3 at Drosophila larval neuromuscular synapses. We find
Rays H Y Jiang et al.
Cell host & microbe, 11(2), 99-100 (2012-02-22)
Survival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway. In a recent Cell paper, Bhattacharjee et al., (2012) describe PI(3)P binding as one of the
Sulochanadevi Baskaran et al.
Molecular cell, 47(3), 339-348 (2012-06-19)
Macroautophagy is essential to cell survival during starvation and proceeds by the growth of a double-membraned phagophore, which engulfs cytosol and other substrates. The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential for autophagy. The key autophagic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 850176P-500UG | 04061835229765 |
| 850176P-100UG | 04061835229758 |