description
1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
InChI
1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-
InChI key
FRWPUPUJRUQWKA-OZTQGENFSA-N
General description
尽管PI(4,5)P2是细胞膜的次要成分，但它作为许多重要信号转导蛋白的底物发挥着重要作用。PI(4,5)P2是IP3/DAG途径中的中间体，在该途径中，它被磷脂酶C水解，释放第二信使，即肌醇1,4,5-三磷酸（IP3）和二酰基甘油（DAG）。PI(4,5)P2也是PI 3-激酶的底物，可被磷酸化为PI(3,4,5)P3，后者是下游信号转导成分（如蛋白激酶AKT）的激活剂。PI(4,5)P2的二辛酰基衍生物比其长链对应物更易溶于水。
Application
08:0 PI(4,5)P2适用于识别瞬时受体电位香草酸4（TRPV4 N）末端的结合位点。它可用于体外结合试验，以测定G蛋白偶联受体激酶（GRK）和β2肾上腺素能受体（β2AR）的结合。
Packaging
带塞子和压接盖的2 mL棕色血清瓶（850185P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850185P-500ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Scott B Hansen et al.
Nature, 477(7365), 495-498 (2011-08-30)
The regulation of ion channel activity by specific lipid molecules is widely recognized as an integral component of electrical signalling in cells. In particular, phosphatidylinositol 4,5-bisphosphate (PIP(2)), a minor yet dynamic phospholipid component of cell membranes, is known to regulate
Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2
Goretzki B, et al.
Structure, 26(12), 1583-1593 (2018)
George Khelashvili et al.
Biochemistry, 51(39), 7685-7698 (2012-09-07)
Syntaxin (STX) is a N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein that binds to the plasma membrane and regulates ion channels and neurotransmitter transporters. Experiments have established the involvement of the N-terminal segment of STX in direct protein-protein interactions and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 850185P-500UG | 04061835229864 |
| 850185P-100UG | 04061835229857 |