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关于此项目
经验公式（希尔记法）:
C52H104NO8P
化学文摘社编号:
分子量:
902.36
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
22:0 PC, 1,2-dibehenoyl-sn-glycero-3-phosphocholine, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (850371P-1g), pkg of 1 × 25 mg (850371P-25mg), pkg of 1 × 500 mg (850371P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850371P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)=O
InChI
1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3
InChI key
HRTBOPUWPUXROO-UHFFFAOYSA-N
General description
Phosphatidylcholines (PCs) are amphipathic molecules, that are mainly located on the outer leaflets of the biological membrane bilayer. Approximately 40–50% of the total cellular phospholipids consists of phosphatidylcholine.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
22:0 PC may be used:
- to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
- to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
- as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)
Biochem/physiol Actions
Phosphatidylcholines (PCs) can serve as lung surfactant.
Packaging
20 mL Clear Glass Screw Cap Vial (850371P-1g)
20 mL Clear Glass Screw Cap Vial (850371P-500mg)
5 mL Amber Glass Screw Cap Vial (850371P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
Bingbing Cheng et al.
Scientific reports, 9(1), 20020-20020 (2019-12-29)
Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may be important for facilitating the clinical adoption of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening, both to ensure safe acoustic exposures, and to achieve repeatable and consistent opening.
Estelle Beguin et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 23-33 (2019-11-17)
Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 850371P-1G | 04061835230617 |
| 850371P-25MG | 04061835230624 |
| 850371P-500MG | 04061835230631 |