产品名称
C24 1-磷酸神经酰胺 (d18:1/24:0), Avanti Research™ - A Croda Brand 860527P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860527P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860527P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)COP([O-])(O)=O.[NH4+]
InChI key
JGGZHGYBRJNAOW-FHPBFELKSA-N
General description
神经酰胺-1-磷酸盐（C1P）是磷脂酸盐的鞘脂类似物。
Application
C24神经酰胺-1-磷酸盐（d18:1/24:0）或N-木质素酰神经酰胺-1-磷酸盐（铵盐）已用作标准品，可通过高效液相色谱法/串联质谱法（LC/MS2）定量分析肌肉组织样品中的神经酰胺含量。
Biochem/physiol Actions
神经酰胺-1-磷酸盐（C1P）是一种促有丝分裂剂，具有抗凋亡和促生存活性。它负调节脂多糖刺激的肿瘤坏死因子-α（TNFα）的产生。C1P还介导炎症反应并有助于吞噬作用。它被认为是激动剂刺激的鞘磷脂代谢的第二个脂质信使。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860527P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Szczepan Józefowski et al.
Journal of immunology (Baltimore, Md. : 1950), 185(11), 6960-6973 (2010-11-03)
LPS is a constituent of cell walls of Gram-negative bacteria that, acting through the CD14/TLR4 receptor complex, causes strong proinflammatory activation of macrophages. In murine peritoneal macrophages and J774 cells, LPS at 1-2 ng/ml induced maximal TNF-α and MIP-2 release
V T Hinkovska-Galcheva et al.
The Journal of biological chemistry, 273(50), 33203-33209 (1998-12-05)
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide
Antonio Gómez-Muñoz et al.
Journal of lipid research, 45(1), 99-105 (2003-10-03)
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 860527P-1MG | 04061835317806 |