产品名称
C8 1-磷酸神经酰胺 (d17:1/8:0), Avanti Research™ - A Croda Brand 860652P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860652P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860652P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(NC(CCCCCCC)=O)COP([O-])(O)=O.[NH4+]
InChI key
QZINIJMZYDYICQ-ITEYRTANSA-N
General description
C8 1-磷酸神经酰胺 (d17:1/8:0)是一种新型的生物活性鞘脂。由神经酰胺激酶（CERK）催化C8-神经酰胺或N-辛酰基-D-赤型-鞘氨醇（C17碱）磷酸化形成。C1P是磷脂酸盐的鞘脂类似物。
Biochem/physiol Actions
1-磷酸神经酰胺（C1P）充当促有丝分裂剂。它具有抗凋亡和生存特性。C1P刺激炎症反应并促进吞噬作用。它还具有负调节脂多糖诱导的肿瘤坏死因子-α（TNFα）产生的能力。C1P被认为是激动剂刺激的鞘磷脂代谢的第二个脂质信使。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860652P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Szczepan Józefowski et al.
Journal of immunology (Baltimore, Md. : 1950), 185(11), 6960-6973 (2010-11-03)
LPS is a constituent of cell walls of Gram-negative bacteria that, acting through the CD14/TLR4 receptor complex, causes strong proinflammatory activation of macrophages. In murine peritoneal macrophages and J774 cells, LPS at 1-2 ng/ml induced maximal TNF-α and MIP-2 release
V T Hinkovska-Galcheva et al.
The Journal of biological chemistry, 273(50), 33203-33209 (1998-12-05)
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide
Antonio Gómez-Muñoz et al.
Journal of lipid research, 45(1), 99-105 (2003-10-03)
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 860652P-1MG | 04061835318940 |