SMC^® Human SNAP-25 High Sensitivity Immunoassay Kit

Synaptosomal-associated protein 25 (SNAP-25) plays a crucial role in synaptic transmission in the nervous system. As a component of the SNARE complex, it facilitates the fusion of synaptic vesicles with the presynaptic membrane, enabling the release of neurotransmitters into the synaptic cleft. By promoting efficient neurotransmitter release, SNAP-25 is essential for proper neuronal communication and signaling.

SNAP-25 has been implicated in various conditions, including Alzheimer′s disease, schizophrenia, and multiple sclerosis. Abnormalities in SNAP-25 expression or function can disrupt synaptic transmission, leading to impaired neuronal communication and contributing to cognitive decline and other symptoms associated with these disorders. Alterations in SNAP-25 levels often correlate with disease severity, highlighting its importance in neuroinflammation and synaptic dysfunction. Understanding the role of SNAP-25 in these processes can help identify potential therapeutic targets and inform strategies aimed at restoring synaptic function and improving outcomes for neurological disorders.

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neurofilament & Neuron Metabolism / Neuronal & Glial Markers / Neurodegenerative Medicine / Neuroscience

96 well assay

• Sensitivity: LLOQ 260 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 130-300,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 112% Plasma: 110% CSF: 97%
• Recovery: Serm: 82% Plasma: 91% CSF: 89%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Although SNAP-25 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, canine samples, the assay has not been verified for these species.

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.