biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4A794, monoclonal
species reactivity
rat, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TERF2(7014)
General description
66 kDa
TRF2是一种广泛表达的蛋白，与端粒长度的控制有关。与TRF1类似，TRF2含有一个Myb相关DNA结合基序。它结合双重TTAGGG重复序列，并位于中期染色体的所有人端粒中。TRF2通过维持端粒终点的正确结构，保护染色体末端。突变型TRF2的使用与TRF2预防原代人细胞衰老的作用有关。最近的研究表明TRF2的抑制导致一些类型的哺乳细胞的细胞凋亡。TRF2 在许多人肿瘤中过度表达，研究表明在小鼠癌症发生模型中TRF2的过度表达是致癌性的。
Immunogen
His标记的融合蛋白，对应于全长TRF2（端粒重复结合因子2），在杆状病毒中表达
Application
抗TRF2 抗体（克隆4A794）是一种小鼠单克隆抗体，可用于检测TRF2 （也称为端粒重复结合因子1 & 已在ICC & WB中进行测试。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
可识别TRF2。
Physical form
形式：纯化
蛋白G纯化
蛋白G纯化的小鼠IgG1，溶于含0.05% 叠氮化钠的PBS中。
Preparation Note
自收到之日起在-20°C可稳定保存2年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Analysis Note
对照
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
阳性抗原对照：货号12-303，Jurkat细胞裂解液。
通过免疫印迹对人Jurka细胞的RIPA 裂解液、HeLa细胞核提取物或大鼠L6 RIPA细胞裂解液进行了常规评估
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
S K Manna et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4927-4934 (2000-10-25)
We and others have reported that IFN-alpha potentiates the apoptotic effects of TNF through a mechanism that is not understood. Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival, we hypothesized
Manale El Idrissi et al.
Journal of experimental & clinical cancer research : CR, 32, 64-64 (2013-09-12)
Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. Telomeres, the chromosome extremities, are protected by specific proteins, the shelterin complex and by additional factors. Besides telomerase dysregulation
Clara Lopes Novo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3632-3642 (2013-06-05)
Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 05-521 | 04053252329319 |