05-666
抗BRCA2抗体，克隆5.23
clone 5.23, Upstate®, from mouse
别名:
Anti BRCC2, Anti-BROVCA2, Anti-FACD, Anti-FAD, Anti-FAD1, Anti-FANCD, Anti-FANCD1, Anti-GLM3, Anti-PNCA2, Anti-XRCC11
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5.23, monoclonal
Application:
ICC, WB
Citations:
11
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
5.23, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... BRCA2(675)
General description
390kDa
Immunogen
GST融合蛋白，对应人BRCA2蛋白的2959-3418位残基
Application
用抗BRCA2抗体，克隆5.23（小鼠单克隆抗体）检测BRCA2，已证明可在WB、ICC中起作用。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
BRCA2
Physical form
0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl与0.05％叠氮化钠。
形式：纯化
蛋白G层析
Preparation Note
储存于2-8°C。 收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于2-8°C。
Analysis Note
对照
阳性抗原对照：货号12-309，HeLa细胞核提取物。添加 等体积Laemmli样品还原性缓冲液至10 μL提取物并 煮沸5分钟以还原制剂。在小型凝胶每个泳道上样20 μg 经还原的提取物。
阳性抗原对照：货号12-309，HeLa细胞核提取物。添加 等体积Laemmli样品还原性缓冲液至10 μL提取物并 煮沸5分钟以还原制剂。在小型凝胶每个泳道上样20 μg 经还原的提取物。
已通过免疫印迹法对HeLa核提取物进行常规评估
Other Notes
由于许可协议限制，无法购买该产品进行转售。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.
Ouyang, KJ; Yagle, MK; Matunis, MJ; Ellis, NA
Frontiers in Genetics null
Down-regulation of BRCA2 expression by collagen type I promotes prostate cancer cell proliferation.
Moro, et al.
The Journal of Biological Chemistry, 280, 22482-22491 (2021)
Loredana Moro et al.
The Journal of biological chemistry, 281(31), 22100-22107 (2006-06-07)
Aberrant interaction of carcinoma cells with basement membranes (BM) is a fundamental pathophysiological process that initiates a series of events resulting in cancer cell invasion and metastasis. In this report, we describe the results of our investigations pertaining to the