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Merck
CN

06-237

Anti-Gsα Antibody

serum, Upstate®

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IP, WB
Citations:
12
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, bovine

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GNAS(2778)

General description

large isoform (52 kDa) and small isoform (45 kDa)

Immunogen

peptide corresponding to the c-terminus of bovine Gsα (RMHLRQYELL); this sequence is present in all three isoforms of human Gsα (Gsα1, Gsα2, and GsαXL)

Application

Anti-Gsα Antibody is an antibody against Gsα for use in IC, IP & WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Biochem/physiol Actions

Recognizes the large and small forms of Gsα; does not cross-react with other G proteins.

Physical form

Protein A purified
Serum diluted 1:1 in PBS.

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Widely expressed
routinely evaluated by immunoblot on rat brain microsomal preparation (Catalog #12-144)

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB1639

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

10 - Combustible liquids

wgk

WGK 2



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Parathyroid hormone signaling via G?s is selectively inhibited by an NH(2)-terminally truncated G?s: implications for pseudohypoparathyroidism.
Svetlana Puzhko,Cynthia Gates Goodyer,Mohammad Amin Kerachian,Lucie Canaff et al.
Journal of Bone and Mineral Research null
Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells.
Colette Galet,Mario Ascoli
Cellular Signalling null
Ablation of the Stimulatory G Protein I?-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D.
Zhu, et al.
Endocrinology, 157, 497-507 (2018)



全球贸易项目编号

货号GTIN
06-23704053252337208