biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... HDAC8(55869)
General description
48 kDa
Immunogen
GST fusion protein corresponding to amino acids 305-377 of human HDAC8
Application
Anti-HDAC8 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC8 also known as histone deacetylase 8 & has been tested in IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Biochem/physiol Actions
HDAC8
Physical form
30% glycerol
Antiserum
Preparation Note
2 years at -20°C
Analysis Note
routinely evaluated by immunoblot in in a nuclear extract of mouse liver
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
I Van den Wyngaert et al.
FEBS letters, 478(1-2), 77-83 (2000-08-03)
To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8. HDAC8 shows a high degree of sequence
J J Buggy et al.
The Biochemical journal, 350 Pt 1, 199-205 (2000-08-06)
Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDACs are known to have key roles in the regulation of cell proliferation [Brehm
E Hu et al.
The Journal of biological chemistry, 275(20), 15254-15264 (2000-04-05)
Histone acetylation alters chromatin state by modifying lysines on histone and plays an important role in modulating gene transcription. A dynamic balance of histone acetylation/deacetylation is maintained by histone acetyltransferases and histone deacetylases. Emerging evidence suggests that a family of
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