biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
packaging
antibody small pack of 25 μL
manufacturer/tradename
Upstate®
technique(s)
ChIP: suitable (ChIP-seq), immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Gene Information
human ... EZH2(2146)
General description
95-100kDa
多梳蛋白家族复合物负责哺乳动物和昆虫中数百个基因的调控。这些蛋白质负责染色质的组装和包装，并诱导组蛋白H3甲基化。EZH2（zeste同源物2的增强子）是蛋白质多梳家族的成员，可参与细胞周期调控。RNAi介导的EZH2敲低会导致H3K27三甲基化损失，该结果表明EZH2可通过Lys27（H3K27）上组蛋白H3的三甲基化抑制转录。该蛋白在激素难治性前列腺癌中大量表达。在乳腺癌等恶性肿瘤中，EZH2表达量增加，同时在体外会促进锚着非依赖和侵袭性生长。
Immunogen
带有His标签的融合蛋白，对应于Zeste同系物2（EZH2）小鼠增强子的残基1-343
Application
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
该抗EZH2抗体经过验证可用于免疫沉淀、蛋白质印迹法和ChIP-seq，以对EZH2进行检测。
Biochem/physiol Actions
EZH2
Physical form
形式：纯化
抗血清
Preparation Note
自发货之日起在2-8°C可稳定保存2年
Analysis Note
对照
K562细胞裂解物、C2C12细胞裂解物
K562细胞裂解物、C2C12细胞裂解物
已通过免疫印迹对HeLa和C2C12细胞的RIPA裂解物进行常规评估
Other Notes
请参考特定批次的数据表。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Landeira, David, et al.
Nature Cell Biology, 12, 618-624 (2010)
Aranzazu Villasante et al.
Theranostics, 6(8), 1119-1130 (2016-06-10)
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Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.
Hawkins, PG; Morris, KV
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 07-689-25UL | 04054839350474 |