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12-140

Src Substrate Peptide

Name: Src Substrate Peptide
Brand: MM

Src Substrate Peptide primarily used in Kinase Assays.

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关于此项目

UNSPSC Code:

12352202

NACRES:

NA.41

eCl@ss:

32160405

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属性

Quality Level

100

mol wt

M_w 1670 Da (1.67 kDa)

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_005417.3, NM_198291.1

UniProt accession no.

P12931

shipped in

wet ice

Gene Information

human ... SRC(6714)

说明

General description

Synthetic peptide (KVEKIGEGTYGVVYK) corresponding to amino acids 6-20 of p34^cdc2.

Biochem/physiol Actions

Protein Target: Src

Target Sub-Family: TK

Physical form

Lyophilized powder

Preparation Note

Stable for 2 years at -20°C

Analysis Note

Routinely evaluated in a protein kinase assay as a substrate for Src (p60^c-src), (14-117) or Lck (p56^lck), active (14-379).

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.

B Y Chang et al.

Molecular and cellular biology, 18(6), 3245-3256 (1998-06-20)

To isolate and characterize proteins that interact with the unique domain and SH3 and SH2 domains of Src and potentially regulate Src activity, we used the yeast two-hybrid assay to screen a human lung fibroblast cDNA library. We identified RACK1

Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells.

C K Szekeres et al.

The Journal of biological chemistry, 275(49), 38831-38841 (2000-08-23)

12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE), a 12-lipoxygenase metabolite of arachidonic acid, has multiple effects on tumor and endothelial cells, including stimulation of invasion and angiogenesis. However, the signaling mechanisms controlling these physiological processes are poorly understood. In a human epidermoid carcinoma cell

Contraction regulation of Akt in rat skeletal muscle.

Kei Sakamoto et al.

The Journal of biological chemistry, 277(14), 11910-11917 (2002-01-26)

The protein serine/threonine kinase Akt/protein kinase B has been recognized as a critical signaling mediator for multiple cell systems. The function of Akt in skeletal muscle is not well understood, and whether contractile activity stimulates Akt activity has been controversial.

全球贸易项目编号

货号	GTIN
12-140	04053252337550
Z193208-2EA	04061833299180
EP6001072510-1EA	04022536228556
EP6001082410-1EA	04022536230436