124038
InSolution Akt 抑制剂 V，曲西立滨-CAS 35943-35-2-Calbiochem
InSolution, ≥95%
别名:
InSolution Akt Inhibitor V, Triciribine
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关于此项目
经验公式（希尔记法）:
C13H16N6O4
化学文摘社编号:
分子量:
320.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
Quality Level
description
RTECS - RY8455000
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
shipped in
ambient
storage temp.
−70°C
SMILES string
[n]2(c3ncnc4c3c(c2)C(=N)NN4C)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChI
1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
InChI key
HOGVTUZUJGHKPL-HTVVRFAVSA-N
General description
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
Packaging
Packaged under inert gas
Physical form
A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012 ) in DMSO.
Preparation Note
Following intitial thaw, aliquot and freeze (-70°C).
Other Notes
Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.
Yang, L., et al. 2004. Cancer Res.64, 4394.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C0636-100G | 04061833450963 |
| 8184240100 | 04022536435640 |
| 8184249025 | 04022536565651 |
| C0636-500G | 04061833450987 |
| 124038-2MG | 04055977205848 |