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14-309

PCAF Protein, Active, 50 µg

Name: PCAF Protein, Active, 50 µg
Brand: MM

PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).

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关于此项目

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Recombinant:

expressed in E. coli

Mol wt:

M_w 79 kDa

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属性

recombinant

expressed in E. coli

Quality Level

100

mol wt

M_w 79 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (histone acetyltransferase (HAT))

NCBI accession no.

NM_003884.3

UniProt accession no.

Q92831

shipped in

dry ice

说明

General description

Product Source: expressed in E. Coli corresponding to amino acids 352-832

Analysis Note

routinely evaluated by acetylation of core histones in vitro

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

wgk

WGK 1

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Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.

Jae-Hwan Lim,Katherine L West,Yaffa Rubinstein,Michael Bergel,Yuri V Postnikov,Michael Bustin

The Embo Journal null

P/CAF-mediated spermidine acetylation regulates histone acetyltransferase activity.

Giosalba Burgio et al.

Journal of enzyme inhibition and medicinal chemistry, 31(sup3), 75-82 (2016-07-09)

Histones and polyamines are important determinants of the chromatin structure. Histones form the core of nucleosome particles and their modification by acetylation of N-terminal tails is involved in chromatin structural changes and transcriptional regulation. Polyamines, including spermidine, are also targets

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates.

R L Schiltz et al.

The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)

A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates

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货号	GTIN
14-309	04053252586798