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14-329-M

JNK2α2/SAPK1a Protein, active, 10 µg

Active, N-terminal His-tagged, full length human JNK2α2/SAPK1a, for use in Kinase Assays.

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UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Biological source:
human
Mol wt:
Mw 49.2 kDa
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biological source

human

Quality Level

100

mol wt

Mw 49.2 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_002752.3, NM_139068.1, NM_139069.1, NM_139070.1

UniProt accession no.

P45984

Gene Information

human ... MAPK9(5601)

General description

N-terminal His-tagged, full length human JNK2α2/SAPK1a
Product Source: Expressed in Sf21 cells

Biochem/physiol Actions

Protein Target: JNK2α2/SAPK1a
Target Sub-Family: CMGC

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-329M when ordering the 250 µg size.

Physical form

Ni2+/NTA-agarose

Preparation Note

6 months at -70°C

Analysis Note

Routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Girish V Putcha et al.
Neuron, 38(6), 899-914 (2003-06-24)
Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
S P Zhong et al.
The Journal of biological chemistry, 275(28), 20980-20984 (2000-05-12)
Histone H3 is the core protein of the nucleosome. Phosphorylation of H3 involves immediate early gene expression, chromatin remodeling, and chromosome condensation during mitosis. Very recently, Rsk2 or MSK1 kinase-mediated phosphorylation of H3 at serine 10 was reported. In the
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全球贸易项目编号

货号GTIN
14-32904053252511875
14-329M04053252618055