165350
PARP抑制剂I, 3-ABA
The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
PARP抑制剂I, 3-ABA
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关于此项目
经验公式（希尔记法）:
C7H8N2O
化学文摘社编号:
分子量:
136.15
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
description
RTECS - CU8992000
Quality Level
assay
≥99% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
ethanol: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
Nc1cc(ccc1)C(=O)N
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
General description
一种细胞可渗透的抗增殖剂，可作为聚（ADP-核糖）聚合酶（PARP）的抑制剂。对细菌毒素介导的ADP-核糖基化作用最小。紫外线诱导的凋亡的抑制剂。还强烈抑制人效应自然杀伤细胞对K562靶细胞的杀伤作用。
Biochem/physiol Actions
主要靶标
PARP
PARP
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存3个月。
Other Notes
Tiozzo, R., et al. 1996.Biochem.Biophys.Res. Commun.225, 826.
Malorni, W., et al. 1995.Biochem.Biophys.Res. Commun.207, 715.
Malorni, W., et al. 1994.Biochem.Biophys.Res. Commun.199, 1250.
Monti, D., et al. 1994.Biochem.Biophys.Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A.1991.Biochem.Biophys.Res. Commun.179, 1225.
Malorni, W., et al. 1995.Biochem.Biophys.Res. Commun.207, 715.
Malorni, W., et al. 1994.Biochem.Biophys.Res. Commun.199, 1250.
Monti, D., et al. 1994.Biochem.Biophys.Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A.1991.Biochem.Biophys.Res. Commun.179, 1225.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
11 - Combustible Solids
wgk
WGK 3
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 165350-100MG | 04055977207675 |