biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
form
liquid
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
dilution
(Immunoblotting (1:5000-1:20,000)
Immunofluorescence (1:1000)
Immunohistochemistry (1:1000)
Immunoprecipitation (1:1000))
isotype
IgG
shipped in
ambient
storage temp.
−20°C
target post-translational modification
unmodified
General description
兔多克隆抗体以未稀释的血清形式提供。识别全长APP和C端可溶性产物CTFγ（~6 kDa）、CTFα（~9 kDa）和CTFβ（~11 kDa）。
兔多克隆抗淀粉样蛋白前体蛋白C末端（751-770）可识别全长APP和C末端可溶性产物CTFα，β和γ。经验证可用于WB、IF、IHC和IP。
识别全长APP和C端可溶性产物CTFγ（~6 kDa）、CTFα（~9 kDa）和CTFβ（~11 kDa）。抗体靶基因符号：APP 靶标异名：AAA，AD1，Adap，AL024401，淀粉样蛋白前体，淀粉样蛋白糖蛋白，APP异构体1，APPI，appican，CTFgamma，CVAP，E030013M08RIK，Nexin II，P3，PN2，PreA4，蛋白酶 NEXIN2 Entrez基因名称：淀粉样β（A4）前体蛋白 Hu Entrez ID：351（相关抗体：PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537) Mu Entrez ID: 11820 大鼠Entrez ID：54226
Immunogen
人
合成肽[(C)KMQQNGYENPTYKFFEQMQN]，对应于人前体蛋白（APP）的751-770位氨基酸，与KLH偶联
Application
免疫印迹（1:5000-1:20,000）
免疫荧光（1:1000）
免疫组织化学（1:1000）
免疫沉淀（1:1000）
免疫荧光（1:1000）
免疫组织化学（1:1000）
免疫沉淀（1:1000）
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Other Notes
Pinnix, I., et al. 2001.J. Biol. Chem.276, 481.
合适的工作稀释度由与测定条件相关的变量决定。
Legal Information
采购本材料仅供研究使用。在将0433抗体或任何衍生物用于临床诊断或治疗目的之前，请用户向Mayo索取许可证。有关许可信息，请联系：Mayo Medical Ventures，技术商业化办公室（507）284-8878，200 First Street SW，Rochester，MN 55905-001。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Systemic inflammation impairs microglial AI? clearance through NLRP3 inflammasome.
Tejera, et al.
The Embo Journal, 38, e101064-e101064 (2020)
Inderjeet Saluja et al.
Neurobiology of disease, 36(1), 162-168 (2009-07-28)
The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9
Ramon Velazquez et al.
Molecular psychiatry, 25(10), 2620-2629 (2019-01-10)
The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine (Hcy) levels double the risk of developing AD.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 171610-50UL | 07790788048150 |