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182515

CK-666

Name: CK-666
Brand: MM

≥95% (HPLC), solid, Arp2/3 complex inhibitor, Calbiochem

别名:

肌动蛋白相关蛋白2/3(Arp2/3)复合物抑制剂I, CK-666, 2-氟-N-(2-(2-甲基-1H-吲哚-3-基)乙基)苯甲酰胺，CK-0944666，肌动蛋白组装抑制剂XIII

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₇FN₂O

化学文摘社编号:

442633-00-3

分子量:

296.34

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03036271

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

产品名称

肌动蛋白相关蛋白2/3(Arp2/3)复合物抑制剂I, CK-666, Arp2/3 Complex Inhibitor I, CK-666, CAS 442633-00-3, is a cell-permeable selective inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex (IC50 = 4 uM in human).

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1c(cccc1)C(=O)NCCc2c3c([nH]c2C)cccc3

InChI

1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChI key

UXRKUKRXVWJFER-UHFFFAOYSA-N

说明

General description

一种可渗透细胞的吲哚基-氟苯甲酰胺化合物，可选择性抑制由人、牛、裂变酵母S. pombe和发芽酵母酿酒酵母起源的肌动蛋白相关蛋白Arp2/3复合物介导的肌动蛋白组装（IC₅₀=4、17、5和12 µM），而不会影响粟酒裂殖酵母formin域Cdc12（FH2）介导的或自发的肌动蛋白聚合。显示以可逆的方式抑制感染的SKOV3细胞（IC₅₀ = 7 µM）中细胞内李斯特菌周围肌动蛋白丝“彗星尾”的形成。结构研究表明，CK-666靶向Arp2的亚结构域4和Arp3的亚结构域1之间形成的口袋，从而防止Arp2/3在N-WASP-VCA结合后转变为活性构象。CK-666和CK-869（目录编号182516）表现出不同的结合方式，导致它们的酵母交叉反应性不同。CK-689（目录编号182517）可作为阴性对照。

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。

Other Notes

Nolen, B.J., et al. 2009.Nature460, 1031.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：监管审查（Z）

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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全球贸易项目编号

货号	GTIN
182515-25MG	04055977205053