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19-142

LY 294002

Name: LY 294002
Brand: MM

别名:

NSC 697286, PI3K inhibitor, SF 1101

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关于此项目

UNSPSC Code:

12352202

NACRES:

NA.41

eCl@ss:

32160405

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属性

form

solid

Quality Level

100

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

shipped in

wet ice

说明

Application

PI 3-激酶的特异性和强效抑制剂。

Biochem/physiol Actions

抑制剂种类：激酶

Physical form

C₁₉H₁₇NO₃

Preparation Note

在-20°C下可保存2年

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

487.4 °F

flash_point_c

253.0 °C

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VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway.

Wen Jiang et al.

Bioengineered, 12(2), 10264-10284 (2021-11-02)

Chronic skin ulcers are a primary global health problem. Velvet antler polypeptide (VAP) regulates endothelial cell migration and angiogenic sprout. Adipose-derived stem cells (ADSCs) are reported to make pivotal impacts upon wound healing. This study aimed to explore the role

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

C J Vlahos et al.

The Journal of biological chemistry, 269(7), 5241-5248 (1994-02-18)

Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and nonreceptor tyrosine kinases, including the platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a better understanding of the function and

Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex.

Satoru Takahashi et al.

The Journal of biological chemistry, 278(33), 30821-30827 (2003-06-12)

Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. We recently used purified proteins to characterize the mechanisms by which heat shock protein 90 (HSP90) increases eNOS activity

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全球贸易项目编号

货号	GTIN
19-142	04053252283116