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BAPTA/AM

Name: BAPTA/AM
Brand: MM

Membrane-permeable form of BAPTA.

别名:

BAPTA/AM, 1,2-双（o-氨基苯氧基）乙烷-N,N,Nʹ,Nʹ-四乙酸四（乙酰氧基甲基）酯

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关于此项目

经验公式（希尔记法）:

C₃₄H₄₀N₂O₁₈

化学文摘社编号:

126150-97-8

分子量:

764.68

UNSPSC Code:

12352108

NACRES:

NA.25

MDL number:

MFCD00036696

Assay:

≥90% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥90% (TLC)

form

solid

reaction suitability

reagent type: chelator

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N(CC(=O)OCOC(=O)C)(CC(=O)OCOC(=O)C)c1c(cccc1)OCCOc2c(cccc2)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

InChI

1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3

InChI key

YJIYWYAMZFVECX-UHFFFAOYSA-N

说明

General description

BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。消除维生素D₃诱导的细胞内Ca²⁺增加。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。

Application

TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.：本文研究如何通过调节乳腺癌细胞中的TRPV1和凋亡通路发挥抗增殖作用，过程中用到钙螯合剂BAPTA/AM(Rumpa et al., 2024)。

Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.：本文体现BAPTA/AM可缓解与肾细胞衰老和肾脏老化过程有关的线粒体钙超载(Xiong et al., 2024)。

TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.：本文研究TRPV3通道如何通过激活NRF2/FSP1通路增强脂解和抗肥胖保护，BAPTA/AM在通道调节实验中起作用(Hu et al., 2024)。

Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.：使用BAPTA/AM调节钙稳态以抑制急性胰腺炎治疗导致的炎症和自身消化(Wang et al., 2024)。

IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.：本文研究BAPTA/AM如何抑制IP3R介导的钙释放，从而减少神经母细胞瘤细胞铁死亡(Campos et al., 2024)。

Packaging

用惰性气体包装

Preparation Note

复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备液可在-20°C最长稳定1个月。

Other Notes

Bissonnette, M., et al. 1994.Am. J. Physiol.267, G465.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c