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203297-M

Bisindolylmaleimide IV

Name: Bisindolylmaleimide IV
Brand: MM

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

别名:

Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₃N₃O₂

化学文摘社编号:

119139-23-0

分子量:

327.34

UNSPSC Code:

12352111

MDL number:

MFCD00236432

NACRES:

NA.77

Assay:

≥98% (TLC)

Form:

powder, solid

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

≥98% (TLC)

form

powder, solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

dark orange

solubility

methanol: 10 mg/mL

storage temp.

2-8°C

SMILES string

N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

说明

General description

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

Biochem/physiol Actions

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c