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DMH1

Name: DMH1
Brand: MM

≥97% (HPLC), solid, BMP inhibitor, Calbiochem^®

别名:

BMP Inhibitor II, DMH1, ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₀N₄O

化学文摘社编号:

1206711-16-1

分子量:

380.44

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD18384963

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

产品名称

BMP Inhibitor II, DMH1, The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

orange

solubility

DMSO: 16.6 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]21ncc(c2ncc(c1)c5ccc(cc5)OC(C)C)c3c4c(ncc3)cccc4

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChI key

JMIFGARJSWXZSH-UHFFFAOYSA-N

说明

General description

A cell-permeable, potent, and highly selective BMPR (bone morphogenetic protein receptor) inhibitior (IC₅₀ against human ALK2/BMPR-I = 107.9 nM) that exhibits no inhibitory activity against ALK5, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Effectively blocks ALK2- and ALK3-, but not ALK6-, mediated transcription activity (IC₅₀<500 nM, <100 nM, and >10 M in reporter assays using C2C12BRA expressing constitutively active ALK2, ALK3, or ALK6, respectively). Comparing to its non-BMPR-selective structural analog dorsomorphin, DMH1 is 12.5-times more potent in preventing BMP pathway-dependent DV (dorsoventral) development (EC₁₀₀ = 0.2 M DMH1 or 2.5 M DM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel (ISV) formation even at concentrations as high as 50 M.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Hao, J., et al. 2010. ACS Chem.Biol.5, 245.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c