205531
CA-074 Me
≥98% (HPLC), solid, Cathepsin B inhibitor, Calbiochem®
别名:
CA-074 Me
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关于此项目
经验公式（希尔记法）:
C19H31N3O6
分子量:
397.47
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
CA-074（目录编号205530）的细胞可渗透类似物，可作为细胞内组织蛋白酶B的不可逆抑制剂。据报道在啮齿动物模型中抑制骨吸收，并在体外显示出抑制B16黑色素瘤细胞侵袭的作用。
Biochem/physiol Actions
主要靶标
组织蛋白酶B
组织蛋白酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：2.24 nM，针对组织蛋白酶B
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Other Notes
Sever, N., et al. 2002.Biol. Chem.383, 839.
Authier, F., et al. 1999.J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994.J. Cell Biochem.56, 118.
Buttle, D.J., et al. 1992.Arch.Biochem.Biophys.299, 377.
Authier, F., et al. 1999.J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994.J. Cell Biochem.56, 118.
Buttle, D.J., et al. 1992.Arch.Biochem.Biophys.299, 377.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Joel Selkrig et al.
Molecular systems biology, 17(2), e10188-e10188 (2021-02-17)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health and has compromised economic stability. In addition to the development of an effective vaccine, it is imperative to understand how SARS-CoV-2 hijacks host cellular machineries
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 205531-1MG | 07790788048433 |