218759
半胱氨酸蛋白酶-8抑制物II
≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem®
别名:
半胱氨酸蛋白酶-8抑制物II, Z-IE(OMe)TD(OMe)-FMK，颗粒酶B抑制剂III
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关于此项目
经验公式（希尔记法）:
C30H43FN4O11
分子量:
654.68
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
半胱氨酸蛋白酶-8抑制物II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to yellow
solubility
DMSO: 10 mM
shipped in
ambient
storage temp.
−20°C
General description
一种有效、细胞可渗透性且不可逆的caspase-8和颗粒酶B的抑制剂。有效抑制流行性感冒病毒诱导的HeLa细胞凋亡。还抑制颗粒酶B。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。也可使用5 mM（250 µg/76 µl）Z-IETD-FMK（目录号218840）的DMSO溶液。
Biochem/physiol Actions
主要靶标
caspase-8
caspase-8
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存8个月。
Analysis Note
≥98%（HPLC）
Other Notes
Takizawa, T., et al. 1999.Microbiol.Immunol.43, 245.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Gurdeep Marwarha et al.
Biomedicines, 10(1) (2022-01-22)
Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia-reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress. However, to date, no consensus has emerged with regards to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 218759-1MG | 04055977218619 |
| 218759-250UG | 04055977218626 |