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220467

2-Chloro-2′-deoxyadenosine

Name: 2-Chloro-2′-deoxyadenosine
Brand: MM

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

别名:

2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₂ClN₅O₃

化学文摘社编号:

4291-63-8

分子量:

285.69

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00153939

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

description

Merck USA index - 14, 2337

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1nc2[n](cnc2c(n1)N)[C@@H]3O[C@@H]([C@H](C3)O)CO

InChI

1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChI key

PTOAARAWEBMLNO-KVQBGUIXSA-N

说明

General description

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

Biochem/physiol Actions

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

Cell permeable: no

Other Notes

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H361fd,H372

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c