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232120

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

别名:

顺铂

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关于此项目

线性分子式:
Pt(NH3)2Cl2
化学文摘社编号:
15663-27-1
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00011623
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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产品名称

顺铂, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Quality Level

100

description

Merck USA index - 14, 2317

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

PBS with 140 mM NaCl: 1 mg/mL, water with 154 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/2Cl.2H3N.Pt/h;;2*1H3;

InChI key

JFUARQHXOQHNLK-UHFFFAOYSA-N

General description

具有强效抗肿瘤活性的铂配位复合物。诱导癌细胞中的凋亡，可能通过caspase-3激活。据报道可使胶质瘤细胞对TNF-α-诱导的凋亡敏感。

注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。

Biochem/physiol Actions

主要靶标
诱导癌细胞凋亡
产物不与ATP竞争。
可逆：否
细胞渗透性：否

Preparation Note

溶液中不稳定；仅在使用前进行复溶。

Other Notes

Hall, M.D., et al. 2014.Cancer Res. In press.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：有毒 & 致癌/致畸性（G）

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

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全球贸易项目编号

货号GTIN
232120-50MG04055977217605