250401
Ciliobrevin D
≥99% (HPLC), powder, cytoplasmic dynein inhibitor, Calbiochem®
别名:
细胞质动力蛋白抑制剂，Ciliobrevin D, 2-（7-氯-4-氧代-3,4-二氢喹唑啉-2（1H）-亚基）-3-（2,4-二氯苯基）-3-氧代丙腈，AAA+ ATPase运动细胞质动力蛋白抑制剂
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关于此项目
经验公式（希尔记法）:
C17H8Cl3N3O2
化学文摘社编号:
分子量:
392.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
细胞质动力蛋白抑制剂，Ciliobrevin D, Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
Quality Level
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
DMSO: 2.5 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
InChI key
JKKSCGHDRHRWOQ-FOWTUZBSSA-N
General description
一种可渗透细胞的苯甲酰二氢喹唑啉酮衍生物，可作为AAA+ATPase运动细胞质动力蛋白的可逆和特异性阻滞剂，并以剂量依赖的方式破坏主轴极聚焦，冷稳定的微管形成，动粒微管附着和黑素体聚集（约10至40 µM）。 显示会干扰原纤毛内的蛋白运输，并导致原纤毛远端的鞭毛内运输蛋白88（IFT88）水平显著增加。据报道破坏了原纤毛依赖性Gli调节并阻断了刺猬信号传导。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Other Notes
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Journal of cell science, 134(16) (2021-08-24)
Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here, we investigated the potential
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eLife, 9 (2020-03-05)
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and
Xiang Zhao et al.
Science advances, 7(24) (2021-06-13)
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymmetry between daughter cells during asymmetric cell division (ACD). How cortically localized Par-3 establishes asymmetric Notch activity in the nucleus is not understood. Here, using
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 250401-10MG | 04055977199161 |