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Merck
CN

329600

Erastin

≥98% (HPLC), solid, ferroptosis inducer, Calbiochem®

别名:

Erastin, 2-(1-(4-(2-(4-氯苯氧基)乙酰基)-哌嗪-1-基)-乙基)-3-(2-乙氧基苯基)-3H-喹唑啉-4-酮

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关于此项目

经验公式(希尔记法):
C30H31ClN4O4
化学文摘社编号:
分子量:
547.04
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
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产品名称

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

General description

具有致癌基因选择性杀伤力的细胞可渗透的哌嗪基-喹唑啉酮化合物。显示结合线粒体电压依赖性阴离子通道(VDAC)并改变其门控;在几种人类肿瘤中快速诱导氧化性,非凋亡性细胞死亡,这些肿瘤在RAS-RAF-MEK信号传导中具有激活突变(在BJ-TERT/LT/ST/RASV12细胞中EC50 = 6.0 µM)。

Packaging

用惰性气体包装

Preparation Note

复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多6个月。

Other Notes

Yagoda, N., et al. 2007.Nature447, 864.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Jiashuo Zheng et al.
Cell death & disease, 12(7), 698-698 (2021-07-15)
Sorafenib, a protein kinase inhibitor approved for the treatment of hepatocellular carcinoma and advanced renal cell carcinoma, has been repeatedly reported to induce ferroptosis by possibly involving inhibition of the cystine/glutamate antiporter, known as system xc-. Using a combination of
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].



全球贸易项目编号

货号GTIN
329600-5MG04055977195651