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341205

依托泊苷

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem

别名:

依托泊苷

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关于此项目

经验公式（希尔记法）:
C29H32O13
化学文摘社编号:
33419-42-0
分子量:
588.56
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00869325
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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产品名称

依托泊苷, A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.

Quality Level

100

description

Merck USA index - 14, 3886

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

O1[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@H]3[C@@H]4[C@@H]([C@@H](c6c3cc7c(c6)OCO7)c5cc(c(c(c5)OC)O)OC)C(=O)OC4)CO[C@H]1C

InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

General description

一种细胞可渗透的拓扑异构酶II抑制剂（IC50 = 59.2 µM）。一种鬼臼毒素衍生物（目录编号540040），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。
一种细胞可渗透的鬼臼毒素衍生物，可用作拓扑异构酶II抑制剂（IC50 = 59.2 µM），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。

Biochem/physiol Actions

主要靶标
拓扑异构酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：59.2 µM，抑制拓扑异构酶II

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

Other Notes

De Lange, A.M., et al. 1995.J. Virol.69, 2082.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
Onishi, Y., et al. 1993.Biochim.Biophys.Acta1175, 147.
Terada, T., et al. 1993.J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991.J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988.J. Clin. Oncol.6, 451.
Issel, B.F.1982.Cancer Chemother.Pharmacol.7, 73.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：有害 & 致癌/致畸性（E）

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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货号GTIN
341205-25MG04055977215434