365251
Gö 6983
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.
别名:
Gö 6983
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关于此项目
经验公式（希尔记法）:
C26H26N4O3
化学文摘社编号:
分子量:
442.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange-red
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)ccc(c3)OC
InChI
1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChI key
LLJJDLHGZUOMQP-UHFFFAOYSA-N
General description
一种有效、细胞可渗透、可逆和ATP竞争性的蛋白激酶C（PKC）抑制剂，可抑制几种PKC同工酶（PKCα和PKCβ的IC50=7 nM；PKCγ的IC50=6 nM；PKCδ的IC50=10 nM；PKCζ的IC50=60 nM）。Gö 6983不能有效抑制PKCµ（IC50 = 20 µM），因此可用于区分PKCµ 与其他PKC同工酶。
一种有效、细胞可渗透的蛋白激酶C（PKC）抑制剂，已被证明可选择性抑制几种PKC同工酶（PKCα和PKCβ的IC50=7 nM；PKCγ的IC50=6 nM；PKCδ的IC50=10 nM；PKCζ的IC50=60 nM）。Gö 6983不能有效抑制PKCµ（IC50 = 20 µM），因此可用于区分PKCµ与其他PKC同工酶。
Biochem/physiol Actions
主要靶标
PKCα 和PKCβ
PKCα 和PKCβ
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：7 nM，对于PKCα 和PKCβ，6 nM，对于PKCγ；10 nM，对于PKCδ；60 nM，对于PKCζ
Other Notes
Wang, D., et al. 1998.J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997.J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Stempka, L., et al. 1997.J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 3
Dilip Kumar et al.
Journal of immunology (Baltimore, Md. : 1950), 182(2), 1011-1020 (2009-01-07)
The MAPKs ERK, JNK, and p38 control diverse aspects of the immune response, including regulation of cytotoxin biology in NK cells and CTL. The chemokine CCL5 is coreleased with the cytotoxins, perforin, the granzymes, and granulysin, during the lethal hit
Vicky García-Hernández et al.
Journal of cellular physiology, 230(1), 105-115 (2014-06-10)
Epidermal Growth Factor (EGF) is a key regulator of epithelial paracellular permeability, a property that depends on tight junctions (TJ) and can be evaluated through the measurement of the transepithelial electrical resistance (TER). EGF increases the TER of MDCK monolayers
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 365251-500UG | 04055977192032 |