400046
Hydroxyurea
≥98% (HPLC), solid, RNR inhibitor, Calbiochem
别名:
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
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关于此项目
产品名称
Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
Quality Level
description
Merck USA index - 14, 4848
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N(O)C(=O)N
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
General description
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
Other Notes
Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kaisa Ikkala et al.
Scientific reports, 12(1), 161-161 (2022-01-09)
The cornea, transparent and outermost structure of camera-type eyes, is prone to environmental challenges, but has remarkable wound healing capabilities which enables to preserve vision. The manner in which cell plasticity impacts wound healing remains to be determined. In this
Pietri Puustinen et al.
Autophagy, 16(10), 1871-1888 (2020-01-28)
Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 400046-5GM | 04055977212129 |