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401484

IKK-2 Inhibitor IV

Name: IKK-2 Inhibitor IV
Brand: MM

InSolution, ≥95%

别名:

InSolution IKK-2 Inhibitor IV

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₀FN₃O₂S

分子量:

279.29

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

liquid

potency

18 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

clear pale yellow

shipped in

wet ice

storage temp.

2-8°C

说明

General description

IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC₅₀ = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC₅₀ in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC₅₀ = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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全球贸易项目编号

货号	GTIN
401484-500UG	04055977211993