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420107-M

Jasplakinolide

Name: Jasplakinolide
Brand: MM

from Jaspis johnstoni, ≥95% (HPLC), F-actin modulator, solid

别名:

Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

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关于此项目

经验公式（希尔记法）:

C₃₆H₄₅BrN₄O₆

化学文摘社编号:

102396-24-7

分子量:

709.67

UNSPSC Code:

12352200

MDL number:

MFCD00873735

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

产品名称

Jasplakinolide, Jaspis johnstoni, A cell-permeable F-actin probe.

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

InChI

1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1

InChI key

GQWYWHOHRVVHAP-HZIRKPFGSA-N

说明

General description

A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca²⁺entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (K_d = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.

Biochem/physiol Actions

Kd = 15 nM for actin binding

Primary Target
Inducer of actin polymerization and stabilization in vitro

Other Notes

Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c