跳转至内容
Merck
CN

主要文件

查看所有文档

474787

MG-132

≥95% (HPLC), proteasome inhibitor, powder

别名:

Z-Leu-Leu-Leu-al, MG-132

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:
C26H41N3O5
化学文摘社编号:
133407-82-6
分子量:
475.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00674886
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

MG-132，HPLC检测显示纯度≥95%, Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).

Quality Level

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 25 mg/mL, ethanol: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

General description

高效、可逆和细胞可透过性蛋白酶体抑制剂(Ki = 4 nM)。通过26S复合物减少哺乳动物细胞和酵母的可渗透染色中泛素结合蛋白的降解，而不会影响其ATPase或异肽酶的活性。可激活c-Jun N端激酶（JNK1），从而启动细胞凋亡。抑制NF-κB的活化（IC50 = 3 µM）。该材料经HPLC测试为≥95%纯。 另提供经HPLC测试为≥98%纯度产品（货号474790）。也可以提供20 mM的DMSO溶液（目录号474788）。

Packaging

用惰性气体包装

Preparation Note

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

Other Notes

Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell 78, 761.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

Still not finding the right product?

Explore all of our products under MG-132，HPLC检测显示纯度≥95%

存储类别

11 - Combustible Solids

wgk

WGK 3

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

相关内容

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.

Sheng Wang et al.
iScience, 24(12), 103441-103441 (2021-12-09)
Extracellular miRNAs (ex-miRNAs) mediate intercellular communication and play a role in diverse physiological and pathological processes. Using small RNA sequencing, we identify that miRNAs are the most abundant RNA species in the plasma and differentially expressed in murine and human
Li Ma et al.
Cancer biology & therapy, 23(1), 1-15 (2022-09-29)
Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high mortality. Recently, bromodomains and extra-terminal (BET) protein inhibitors have been extensively researched in hematological tumors as potential
Wei Wang et al.
The Journal of biological chemistry, 299(2), 102851-102851 (2023-01-02)
Misfolded proteins are recognized and degraded through protein quality control (PQC) pathways, which are essential for maintaining proteostasis and normal cellular functions. Defects in PQC can result in disease, including cancer, cardiovascular disease, and neurodegeneration. The small ubiquitin-related modifiers (SUMOs)
查看所有相关文献

全球贸易项目编号

货号GTIN
474787-10MG04055977185454