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474790

MG-132

≥98% (HPLC), proteasome inhibitor, solid

别名:

Z-Leu-Leu-Leu-al, MG-132

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关于此项目

经验公式（希尔记法）:
C26H41N3O5
化学文摘社编号:
133407-82-6
分子量:
475.62
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD00674886
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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产品名称

MG-132, A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 20 mg/mL, ethanol: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

General description

高效、可逆和细胞可透过性蛋白酶体抑制剂（(Ki = 4 nM）。可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解，而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶（JNK1），从而启动细胞凋亡。抑制NF-κB的活化（IC50 = 3 µM）。也有报道称，间充质干细胞移植后的存活率增加。防止β-分泌酶裂解。也可购买10 mM（1 mg/210 µl）MG-132 DMSO溶液（货号474791）。HPLC法测定该物质纯度≥98%。另提供经HPLC测试为≥95%纯度产品（货号474787）。

Biochem/physiol Actions

4 nM抗蛋白酶体
主要靶标
蛋白酶体
产品不与ATP竞争。
可逆性：是
细胞渗透性：是
靶标IC50：3 µM抑制NF-κB活化

Preparation Note

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存1个月。

Other Notes

Li, Z.W. et al. 2011.Sheng Li Xue Bao.63, 525.
Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.
Cell 78, 761.
Z-Leu-Leu-Leu-CHO

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

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存储类别

11 - Combustible Solids

wgk

WGK 3

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