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474791

MG-132

≥98% (HPLC), proteasome inhibitor, liquid

别名:

Z-Leu-Leu-Leu-al, InSolution MG-132, 碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸，Z-LLL-CHO，蛋白酶体抑制剂XI, MG-132

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关于此项目

经验公式（希尔记法）:
C26H41N3O5
化学文摘社编号:
133407-82-6
分子量:
475.62
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD00674886
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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产品名称

MG-132, InSolution, ≥98%, 10 mM, reversible proteasome inhibitor

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

General description

高效、可逆和细胞可透过性蛋白酶体抑制剂（(Ki = 4 nM）。可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解，而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶（JNK1）、抑制NF-κB的活化（IC50 = 3 µM）。

Biochem/physiol Actions

产品不与ATP竞争。
可逆性：是
细胞渗透性：是
靶标IC50：3 µM抑制NF-κB活化
靶标Ki：4 nM作为蛋白酶体抑制剂

Packaging

用惰性气体包装

Physical form

10 mM（1 mg/210 µl）或（5 mg/1050 l）MG-132 DMSO溶液（货号474790）提供。

Other Notes

Meriin, A.B., et al. 1998.J. Biol. Chem.273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Lee, D.H., and Goldberg, A.L.1996.J. Biol. Chem.271, 27280.
Wiertz, E.J.H.J., et al. 1996.Cell84, 769.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell78, 761.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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全球贸易项目编号

货号GTIN
474791-1MG04055977185515
474791-5MG04055977185522