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475856

Mdivi-1

Name: Mdivi-1
Brand: MM

≥95% (HPLC), dynamin-related GTPases inhibitor, solid

别名:

线粒体分裂抑制剂，mdivi-1

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₀Cl₂N₂O₂S

化学文摘社编号:

338967-87-6

分子量:

353.22

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00974506

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

产品名称

线粒体分裂抑制剂，mdivi-1, The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Sc1[n]([c](c3c(n1)cccc3)=O)c2c(cc(c(c2)OC)Cl)Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

说明

General description

一种可渗透细胞的喹唑啉酮化合物，可抑制酵母（Dnm1）和哺乳动物（Drp1）分裂DRP（与发动蛋白相关的GTPases），并以可逆的方式有效诱导线粒体融合成网状结构（在酵母和COS培养物中IC₅₀分别为10和50 M）。无细胞研究表明，mdivi-1通过基于变构调节的机制阻断Dnm1 ATP酶活性（IC₅₀<10 M）和自组装。通过细胞色素C释放评估，Mdivi-1分别在HeLa培养物和无细胞鼠肝线粒体制剂中有效抑制STS和C8-Bid诱导的MOMP（线粒体外膜通透性）。

Packaging

用惰性气体包装

Other Notes

Cassidy-Stone A., et al. 2008.Dev.Cell14, 193.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

Ann Cassidy-Stone et al.

Developmental cell, 14(2), 193-204 (2008-02-13)

Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechanism. We

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.

Yongqi Zhen et al.

Cell death & disease, 13(4), 375-375 (2022-04-21)

Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that the anthelmintic drug flubendazole induced autophagy and apoptosis via upregulation of eva-1 homolog A (EVA1A) in triple-negative breast cancer

全球贸易项目编号

货号	GTIN
475856-10MG	07790788056377