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484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

Name: 5-Nitro-2-(3-phenylpropylamino)benzoic Acid
Brand: MM

Potent Cl⁻ channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method.

别名:

5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₆N₂O₄

化学文摘社编号:

107254-86-4

分子量:

300.31

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD00153851

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

yellow

solubility

DMSO: 5 mg/mL, warm ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[N+](=O)([O-])c1cc(c(cc1)NCCCc2ccccc2)C(=O)O

InChI

1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChI key

WBSMIPAMAXNXFS-UHFFFAOYSA-N

说明

General description

Potent Cl^– channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

Potent Cl^- channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cl⁻ channel blocker

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM-100 µM as Cl-channel blocker

Other Notes

Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c