487928
诺考达唑
≥99% (HPLC), solid, microtuble inhibitor, Calbiochem
别名:
诺考达唑, R17934，甲基-[5-（2-噻吩羰基）-1H-苯并咪唑-2-基]-氨基甲酸酯
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C14H11N3O3S
化学文摘社编号:
分子量:
301.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
诺考达唑, Inhibitor of mitosis.
Quality Level
description
RTECS - DD6521000
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
pale yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
General description
有丝分裂抑制剂。对培养中的哺乳动物细胞具有高度特异性的抗微管活性。促进微管蛋白解聚。也可以50 mM的DMSO溶液（货号487929）提供。
Biochem/physiol Actions
主要靶标
促进微管蛋白解聚
促进微管蛋白解聚
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。贮备液在4°C下可稳定长达1周，在-20°C下可稳定长达1年。
Other Notes
Park, H., et al. 2011.Chem. Med. Chem.in press.
Bunz, F., et al. 1998.Science 282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.
Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
Bunz, F., et al. 1998.Science 282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.
Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
Still not finding the right product?
Explore all of our products under 诺考达唑
signalword
Warning
hcodes
Hazard Classifications
Muta. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Archan Ganguly et al.
Neuron, 109(18), 2884-2901 (2021-09-18)
In non-neuronal cells, clathrin has established roles in endocytosis, with clathrin cages enclosing plasma membrane infoldings, followed by rapid disassembly and reuse of monomers. However, in neurons, clathrin is conveyed in slow axonal transport over days to weeks, and the
Luis Cedeno-Rosario et al.
The Journal of biological chemistry, 298(8), 102263-102263 (2022-07-18)
Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase kinase kinase that promotes the activation of multiple mitogen-activated protein kinase pathways and is required for invasion and proliferation of ovarian cancer cells. Inhibition of MLK activity causes G2/M
Stéphanie Torrino et al.
Cell metabolism, 33(7), 1342-1357 (2021-06-09)
Mechanical signals from the tumor microenvironment modulate cell mechanics and influence cell metabolism to promote cancer aggressiveness. Cells withstand external forces by adjusting the stiffness of their cytoskeleton. Microtubules (MTs) act as compression-bearing elements. Yet how cancer cells regulate MT
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 487928-10MG | 04055977200386 |