487929-M
诺考达唑
≥97% (HPLC), Mitosis inhibitor, liquid
别名:
InSolution诺考达唑, 甲基-（5-（2-噻吩羰基）-1H-苯并咪唑-2-基）-氨基甲酸酯，甲基-5-（噻吩-2-羰基）-1H-苯并[d]咪唑-2-基氨基甲酸酯，R17934
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关于此项目
经验公式（希尔记法）:
C14H11N3O3S
化学文摘社编号:
分子量:
301.32
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
产品名称
诺考达唑, InSolution, ≥97%, 50 mM in DMSO, Inhibitor of mammalian cell mitosis via a highly aspecific antimicrotubular activity
Quality Level
assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
storage temp.
−70°C
SMILES string
[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI key
KYRVNWMVYQXFEU-UHFFFAOYSA-N
General description
有丝分裂抑制剂。对培养中的哺乳动物细胞具有高度特异性的抗微管活性。促进微管蛋白解聚。还可作为癌症相关激酶ABL，c-KIT，BRAF和MEK（Kd<2 M). The solid form of this compound (Cat. No. 487928 ）的高亲和力配体。
Biochem/physiol Actions
主要靶标
微管
微管
次级靶标
特定激酶
特定激酶
Physical form
50 mM（10 mg/664µL）诺考达唑（目录号487928）的DMSO溶液。
Preparation Note
初次解冻后，分装冻存（-70°C）。分装后在-70°C下可稳定保存1年。
Other Notes
Park, H., et al. 2012.Chem. Med. Chem.7, 53.
Bunz, F., et al. 1998.Science282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci.102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
Bunz, F., et al. 1998.Science282, 1497.
Fleischman, L.F., et al. 1993.Oncogene8, 771.Pomies, P., and Block, M.R.1992.Biochem.Biophys.Res. Commun.189, 1429.
Rennison, M.E., et al. 1992.J. Cell Sci.102, 239.
Thyberg, J., and Moskalewski, S. 1992.J. Cell Sci.103, 1167.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
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signalword
Warning
hcodes
Hazard Classifications
Muta. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (refers to pure substance)
flash_point_c
87 °C - closed cup - (refers to pure substance)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 487929-10MG | 04055977200393 |