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513001

PD 98059

Name: PD 98059
Brand: MM

≥98% (HPLC), MAPK pathway inhibitor and AMPK activator, liquid

别名:

InSolution PD 98059, MEK Inhibitor V

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₃NO₃

化学文摘社编号:

167869-21-8

分子量:

267.28

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00671789

Assay:

≥98% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

产品名称

PD 98059, InSolution, ≥98%, 5 mg/ml, reversible inhibitor of MAP Kinase Kinase (MEK)

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

shipped in

wet ice

storage temp.

−20°C

SMILES string

Nc1c(cccc1c2[o]c3c([c](c2)=O)cccc3)OC

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

说明

General description

Selective and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase of MAP kinase activity produced by nerve growth factor (NGF; IC₅₀ = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the pp140^trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Inhibits cell growth and reverses the phenotype of ras-transformed BALB 3T3 mouse fibroblasts and rat kidney cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MAP kinase kinase (MEK)

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2 µM in completely blocking the 4-fold increase in MAP kinase activity produced by nerve growth factor in PC12 cells

Packaging

Packaged under inert gas

Physical form

A 5 mg/ml solution of PD 98059 (Cat. No. 513000) in anhydrous DMSO.

Preparation Note

Following initial thaw, aliquot and freeze.

Other Notes

Kültz, D., et al. 1998. J. Biol. Chem.273, 13645.
Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA92, 7686.
Langlois, W.J., et al. 1995. J. Biol. Chem.270, 25320.
Pang, L., et al. 1995. J. Biol. Chem.270, 13585.
Waters, S.B., et al. 1995. J. Biol. Chem.270, 20883.

Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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全球贸易项目编号

货号	GTIN
513001-1ML	07790788050924