527450
Imidazolo-oxindole PKR inhibitor C16
≥90% (HPLC), solid, PKR inhibitor, Calbiochem®
别名:
PKR 抑制剂
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关于此项目
经验公式（希尔记法）:
C13H8N4OS
化学文摘社编号:
分子量:
268.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
PKR 抑制剂, The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange to orange-brown
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[s]1c2c(nc1)ccc3c2\C(=C\c4nc[nH]c4)\C(=O)N3
InChI
1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChI key
VFBGXTUGODTSPK-BAQGIRSFSA-N
General description
一种咪唑-羟吲哚化合物，作为PKR的一种有效的ATP结合位点定向抑制剂。显示可有效抑制RNA诱导的PKR自磷酸化（IC50 =210 nM）并挽救PKR依赖性翻译阻断（IC50=100 nM）。另提供失活对照。显示可增加持久突触增强的晚期阶段，并增强小鼠的长期记忆。也可以50 mM的DMSO溶液形式（货号527451）提供。
Biochem/physiol Actions
主要靶标
PKR
PKR
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：210 nM抑制RNA诱导的PKR自磷酸化，100 nM挽救PKR依赖性翻译阻断
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Zhu, P.J., et al. 2011.Cell147, 1384.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：致癌/致畸（D）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lasse Reimer et al.
Brain pathology (Zurich, Switzerland), 31(1), 103-119 (2020-07-28)
Deposition of extensively hyperphosphorylated tau in specific brain cells is a clear pathological hallmark in Alzheimer's disease and a number of other neurodegenerative disorders, collectively termed the tauopathies. Furthermore, hyperphosphorylation of tau prevents it from fulfilling its physiological role as
Upayan Patra et al.
Oxidative medicine and cellular longevity, 2020, 7289120-7289120 (2020-04-24)
Eukaryotic cells adopt highly tuned stress response physiology under threats of exogenous stressors including viruses to maintain cellular homeostasis. Not surprisingly, avoidance of cellular stress response pathways is an essential facet of virus-induced obligatory host reprogramming to invoke a cellular
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 527450-5MG | 07790788055615 |