553030
FPS-ZM1
≥98% (HPLC), semisolid,viscous liquid, RAGE antagonist, Calbiochem®
别名:
RAGE 拮抗剂, FPS-ZM1
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C20H22ClNO
化学文摘社编号:
分子量:
327.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
semisolid, viscous liquid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
RAGE 拮抗剂, FPS-ZM1, RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against Aβ40, HMGB1 & S100B, binding to sRAGE).
Quality Level
assay
≥98% (HPLC)
form
semisolid, viscous liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C(Cl)C=C1)N(CC2=CC=CC=C2)C3CCCCC3
InChI
1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
InChI key
XDFKWGIBQMHSOH-UHFFFAOYSA-N
General description
一种血脑屏障渗透性、无毒的叔酰胺化合物，作为RAGE（晚期糖基化终末产物受体）V结构域介导的配体结合的高亲和力、强效、多模式阻断剂（针对Aβ40、HMGB1和S100B，与sRAGE结合，Ki分别为25、148和230 nM）。阻断RAGE介导的Aβ40和Aβ42流入大脑。还显示出抑制Aβ-RAGE诱导的NF-κB激活和NF-κB-依赖性β-分泌酶转录。据报道，每日对APPsw/0小鼠AD模型（1 mg/kg/d，通过ip）进行治疗，可显著减少皮质和海马体中的硫黄素S阳性淀粉样斑块（减少70%至80%），并将认知能力恢复到非AD小鼠的水平。
Biochem/physiol Actions
主要靶标
RAGE
RAGE
可逆性：是
细胞可渗透性：是
靶标Ki：对A&beta分别为25、148和230 nM
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Deane, R., et al. 2012.J. Clin. Invest.122, 1377.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jianghong Zhong et al.
Communications biology, 4(1), 865-865 (2021-07-15)
A single-nucleotide polymorphism of neutrophil cytosolic factor 1 (Ncf1), leading to an impaired generation of reactive oxygen species (ROS), is a causative genetic factor for autoimmune disease. To study a possible tumor protection effect by the Ncf1 mutation in a
Rajkishor Nishad et al.
BMJ open diabetes research & care, 8(1) (2020-07-01)
Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical component of the glomerular filtration
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 553030-25MG | 04055977193466 |