557440
Ru360
≥97%, solid, Ca2+ uptake blocker in mitrochondria, Calbiochem®
别名:
Ru360
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关于此项目
经验公式（希尔记法）:
C2H26Cl3N8O5Ru2
分子量:
550.78
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97%
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
Ru360, Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM).
Quality Level
assay
≥97%
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
green
solubility
deoxygenated water: 0.5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
一种可渗透性氧桥联双核钌胺络合物，已显示出与线粒体结合的高亲和力 (Kd = 0.34 nM)并可特异性阻断Ca2+在体外（IC50 = 184 pM）线粒体中和在原位完整心肌细胞中的摄取（在~10 µM的Ru360中孵育30分钟后完全阻断。即使在微摩尔水平下也不会影响参与心肌收缩的其他细胞Ca2+转运过程。
一种细胞渗透性氧桥联双核钌胺络合物，已显示出与线粒体结合的高亲和力 (Kd = 340 pM)。特异性阻断Ca2+在体外（IC50 = 184 pM）线粒体中和在原位完整心肌细胞中的摄取（在~10 µM的Ru360中孵育30分钟后完全阻断）。即使在微摩尔水平下也不会影响参与心肌收缩的其他细胞Ca2+转运过程。
注意：1组 = 10 x 100 µg.
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：184 pM 阻断Ca2+在体外摄取至线粒体中；以及在原位完整心肌细胞中；结合线粒体的Kd = 340 pM
首要靶标
Ca2+在体外摄取至线粒体中
Ca2+在体外摄取至线粒体中
Packaging
用惰性气体包装
Preparation Note
溶液中不稳定；仅在使用前进行重悬。
Other Notes
Sanchez, J.A., et al. 2001.J. Physiol. 536, 387.
Bassani, R.A., et al. 1998.Cell Calcium23, 433.
Matlib, M.A., et al. 1998.J. Biol. Chem.273, 10223.
Zhou, Z., et al. 1998.J. Physiol.507 (pt 2), 379.
Emerson, J., et al. 1993.J. Am. Chem. Soc.115, 11799.
Ying, W.-L., et al. 1991.Biochemistry30, 4949.
Bassani, R.A., et al. 1998.Cell Calcium23, 433.
Matlib, M.A., et al. 1998.J. Biol. Chem.273, 10223.
Zhou, Z., et al. 1998.J. Physiol.507 (pt 2), 379.
Emerson, J., et al. 1993.J. Am. Chem. Soc.115, 11799.
Ying, W.-L., et al. 1991.Biochemistry30, 4949.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 557440-1SET | 07790788051501 |
| 557440-500UG | 04055977268089 |