557525
Ro-32-0432
A selective cell-permeable protein kinase C inhibitor.
别名:
Ro-32-0432
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选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C28H28N4O2 · xHCl
化学文摘社编号:
分子量:
452.55 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
red
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Cl.[n]21c3c(cc2CC(CC1)CN(C)C)ccc(c3)C4=C(C(=O)NC4=O)c5c6c([n](c5)C)cccc6
InChI
1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H
InChI key
WMVQGKBSNAIMHI-UHFFFAOYSA-N
General description
一种选择性的细胞渗透性蛋白激酶C抑制剂。与ε (IC50=108 nM）相比，PKCα (IC50=9 nM）的选择性提高约10倍，PKCβI (IC50=28 nM）的选择性提高4倍。还可以防止体内T细胞驱动的慢性炎症反应。
请注意，由于水含量的变化，该化合物的分子量因批次而异。
请注意，由于水含量的变化，该化合物的分子量因批次而异。
Biochem/physiol Actions
主要靶标
PKCα
PKCα
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：对于PKCα，PKCβI和PKCε分别为9 nM、28 nM、108 nM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多4个月。
Other Notes
Birchall, A.M., et al. 1994.J. Pharmacol.Exp.Ther.268, 922.
Wilkinson, S.E., et al. 1993.Biochem.J.294, 335.
Wilkinson, S.E., et al. 1993.Biochem.J.294, 335.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
Katryna Pampuscenko et al.
Journal of neurochemistry, 154(3), 316-329 (2019-12-14)
Tau is a microtubule-associated protein, found at high levels in neurons, and its aggregation is associated with neurodegeneration. Recently, it was found that tau can be actively secreted from neurons, but the effects of extracellular tau on neuronal viability are unclear.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 557525-1MG | 04055977193008 |