567430
丁酸钠
≥98% (titration), apoptosis inducer, solid
别名:
丁酸钠, 丁酸，Na，NaB，HDAC抑制剂V
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关于此项目
经验公式（希尔记法）:
C4H7NaO2
化学文摘社编号:
分子量:
110.09
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (titration)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
产品名称
丁酸钠, A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway.
Quality Level
description
RTECS - ET6400000
assay
≥98% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 2 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[Na+].[O-]C(=O)CCC
InChI
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChI key
MFBOGIVSZKQAPD-UHFFFAOYSA-M
General description
一种短链脂肪酸，已被证明可通过不依赖p53的途径诱导结肠癌细胞系中的细胞凋亡。抑制c-myc剪接并干扰信号转导过程，包括从细胞内储存中释放Ca2+。减少C6神经胶质瘤细胞中组胺诱导的钙动员。下调HT29细胞中丝氨酸/苏氨酸蛋白激酶酪蛋白激酶II的活性。
Biochem/physiol Actions
主靶
诱导细胞凋亡
诱导细胞凋亡
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Ou, H.C., et al. 1997.Neuroreport 8, 1375.
Russo, G.L., et al. 1997.Biochem.Biophys.Res. Commun.233, 673.
Krupitza, G., et al. 1995.Carcinogenesis16, 1199.
Calabresse, C., et al. 1993.Biochem.Biophys.Res. Commun.195, 31.
Hague, A., et al. 1993.Int. J. Cancer55, 498.
Russo, G.L., et al. 1997.Biochem.Biophys.Res. Commun.233, 673.
Krupitza, G., et al. 1995.Carcinogenesis16, 1199.
Calabresse, C., et al. 1993.Biochem.Biophys.Res. Commun.195, 31.
Hague, A., et al. 1993.Int. J. Cancer55, 498.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
C Pellegrini et al.
NPJ Parkinson's disease, 8(1), 9-9 (2022-01-14)
Bowel inflammation, impaired intestinal epithelial barrier (IEB), and gut dysbiosis could represent early events in Parkinson's disease (PD). This study examined, in a descriptive manner, the correlation among enteric α-synuclein, bowel inflammation, impairments of IEB and alterations of enteric bacteria
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 567430-250MG | 04055977267273 |