567540
原钒酸钠
A broad spectrum potent inhibitor of protein tyrosine phosphatases.
别名:
原钒酸钠, PTP抑制剂X
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
Na3O4V
化学文摘社编号:
分子量:
183.91
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Quality Level
description
RTECS - YW1120000
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[V](=O)([O-])([O-])[O-].[Na+].[Na+].[Na+]
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
InChI key
IHIXIJGXTJIKRB-UHFFFAOYSA-N
General description
一种广谱有效的蛋白质酪氨酸磷酸酶抑制剂。也可抑制Na+、K+ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶。最近研究表明，在微摩尔范围内，可抑制鼠伤寒沙门氏菌麦芽糖（MalFGK2）重组结合蛋白依赖性ATP结合盒（ABC）转运体的ATP酶活性。可通过过氧化氢转化为过钒酸盐。
Biochem/physiol Actions
主要靶标
Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶
Na+、K+-ATP酶、酸性和碱性磷酸酶、磷酸果糖激酶和腺苷酸激酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Huyer, G., et al. 1997.J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995.Biochem.Biophys.Res. Commun.216, 589.
Levchuck, S.G., et al. 1994.Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989.Biochem.J.262, 83.
Swarup, G., et al. 1982.Biochem.Biophys.Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A.1979.Biochem.J.181, 247.
Hunke, S., et al. 1995.Biochem.Biophys.Res. Commun.216, 589.
Levchuck, S.G., et al. 1994.Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989.Biochem.J.262, 83.
Swarup, G., et al. 1982.Biochem.Biophys.Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A.1979.Biochem.J.181, 247.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
Still not finding the right product?
Explore all of our products under 原钒酸钠
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
Seungkirl Ahn et al.
The Journal of biological chemistry, 277(29), 26642-26651 (2002-05-16)
Endocytosis of ligand-activated receptors requires dynamin-mediated GTP hydrolysis, which is regulated by dynamin self-assembly. Here, we demonstrate that phosphorylation of dynamin I by c-Src induces its self-assembly and increases its GTPase activity. Electron microscopic analyses reveal that tyrosine-phosphorylated dynamin I
Fan Xia et al.
Redox biology, 52, 102284-102284 (2022-03-30)
Autophagy is an evolutionarily conserved self-protecting mechanism implicated in cellular homeostasis. ATG4B plays a vital role in autophagy process via undertaking priming and delipidation of LC3. Chemical inhibitors and regulative modifications such as oxidation of ATG4B have been demonstrated to
Tina Branscombe Miranda et al.
FEBS letters, 577(1-2), 181-186 (2004-11-06)
It has been reported that S-adenosylmethionine-dependent protein methylation in rat kidney extracts can be greatly stimulated by tyrphostin A25, a tyrosine kinase inhibitor. We have investigated the nature of this stimulation. We find that addition of tyrphostin A25, in combination
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 567540-5GM | 04055977266689 |