574215
萝卜硫素
≥98% (UPLC), liquid, phase II detoxifying enzymes inducer, Calbiochem®
别名:
萝卜硫素, 1-异硫氰基-4-(甲基亚硫酰基)丁烷，R,S-萝卜硫素
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关于此项目
经验公式（希尔记法）:
C6H11NOS2
化学文摘社编号:
分子量:
177.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (UPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
萝卜硫素, An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
Quality Level
assay
≥98% (UPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
slight yellow
solubility
ethanol: 10 mg/mL, DMSO: 20 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[S](=O)(CCCCN=C=S)C
InChI
1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChI key
SUVMJBTUFCVSAD-UHFFFAOYSA-N
General description
从花椰菜中分离的异硫氰酸酯，在小鼠组织和培养的小鼠肝癌细胞中作为II期解毒酶的有效诱导剂。它已被证明是预防大鼠化学诱导的乳腺肿瘤的有效药物。它还抑制与致癌物激活相关的I期细胞色素P450同功酶2E1和IA2。II期酶的诱导是通过丝裂原活化蛋白激酶（MAPK）途径介导的。
Biochem/physiol Actions
主靶
小鼠组织和培养的小鼠肝癌细胞中II期解毒酶的有效诱导剂
小鼠组织和培养的小鼠肝癌细胞中II期解毒酶的有效诱导剂
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻DMSO贮备液（-20°C）和乙醇贮备液(-70°C)。DMSO贮备溶液在-20°C下可稳定保存长达3个月，在-70°C下可稳定保存长达3个月。
Other Notes
Gamet-Payrastre, L., et al. 2000.Cancer Res.60, 1426.
Yu, R., et al. 2000.J. Biol. Chem.275, 2322.
Yu, R., et al. 1999.J. Biol. Chem.274, 27545.
Barcelo, S., et al. 1998.Mutat.Res.402, 111.
Maheo, K., et al. 1997.Cancer Res.57, 3649.
Zhang, Y., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3147.
Zhang, Y., et al. 1992.Proc.Natl.Acad.Sci. USA89, 2399.
Yu, R., et al. 2000.J. Biol. Chem.275, 2322.
Yu, R., et al. 1999.J. Biol. Chem.274, 27545.
Barcelo, S., et al. 1998.Mutat.Res.402, 111.
Maheo, K., et al. 1997.Cancer Res.57, 3649.
Zhang, Y., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3147.
Zhang, Y., et al. 1992.Proc.Natl.Acad.Sci. USA89, 2399.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
10 - Combustible liquids
wgk
WGK 3
Yuting Yan et al.
Cell death & disease, 12(10), 917-917 (2021-10-09)
We previously demonstrated that sulforaphane (SFN) inhibited autophagy leading to apoptosis in human non-small cell lung cancer (NSCLC) cells, but the underlying subcellular mechanisms were unknown. Hereby, high-performance liquid chromatography-tandem mass spectrometry uncovered that SFN regulated the production of lipoproteins
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 574215-25MG | 04055977189568 |